产品货号：
GS4416
中文名称：
重组绵羊IFN-τ
英文名称：
Recombinant Ovine Interferon-tau
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 19.9kDa,a single non-glycosylated polypeptide chain containing 172 amino acids.
储存条件：冷冻（-20℃）
概述
IFN-τ is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep.IFN-τ has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/β.The current investigation concerns the effect of recombinant ovine IFN-tau(rOvIFN-τ)on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial(CVE)cells.IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the expression of MHC class I on CVE.One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression.IFN-τwas shown to down regulate IFN-γ-induced MHC class II expression on CVE and,hence,may be of potential therapeutic value in down regulating inflammation in the central nervous system(CNS).IFN-τdid not upregulate the expression of MHC class II on CVE.IFN-τalso inhibited the replication of Theilers virus in CVE.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组绵羊IFN-τ，IFN-τ, Ovine，Recombinant Ovine Interferon-tau
储存条件：冷冻（-20℃）
概述
IFN-τ is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep.IFN-τ has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-α/β.The current investigation concerns the effect of recombinant ovine IFN-tau(rOvIFN-τ)on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial(CVE)cells.IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the expression of MHC class I on CVE.One proposed action by which type I IFN reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression.IFN-τwas shown to down regulate IFN-γ-induced MHC class II expression on CVE and,hence,may be of potential therapeutic value in down regulating inflammation in the central nervous system(CNS).IFN-τdid not upregulate the expression of MHC class II on CVE.IFN-τalso inhibited the replication of Theilers virus in CVE.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Pichia Pastoris |
| 生物活性 | Fully biologically active when compared to IFN-alpha.The specific activity determined by a viral resistance assay is no less than 1.0×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rOvIFN-τ as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | CYLSRKLMLD ARENLKLLDR MNRLSPHSCL QDRKDFGLPQ EMVEGDQLQK DQAFPVLYEM LQQSFNLFYT EHSSAAWDTT LLEQLCTGLQ QQLDHLDTCR GQVMGEEDSE LGNMDPIVTV KKYFQGIYDY LQEKGYSDCA WEIVRVEMMR ALTVSTTLQK RLTKMGGDLN SP |
相关搜索：重组绵羊IFN-τ，IFN-τ, Ovine，Recombinant Ovine Interferon-tau